substance (Noun) — The real physical matter of which a person or thing consists. ex. "DNA is the substance of our genes"
substance (Noun) — The choicest or most essential or most vital part of some idea or experience. ex. "the substance of the prosecutor's argument"
substance (Noun) — The idea that is intended. ex. "What is the substance of this proverb?"
substance (Noun) — Material of a particular kind or constitution. ex. "the immune response recognizes invading substances"
substance (Noun) — Considerable capital (wealth or income). ex. "he is a man of substance"
substance (Noun) — What a communication is about; the information conveyed or area of interest.
substance (Noun) — A particular kind or species of matter with uniform properties. ex. "shigella is one of the most toxic substances known to man"
substance (Noun) — The property of holding together and retaining its shape. ex. "when the dough has enough substance it is ready to bake"