screwup (Noun) — The complete mismanagement or mishandling of a situation. ex. "a typical bureaucratic screwup"
screwup (Verb) — Make a mess of, destroy or ruin. ex. "the pianist screwed up the difficult passage in the second movement"
screwup (Verb) — Make more intense. ex. "Emotions were screwed up"
screwup (Verb) — Screw or turn higher.
screwup (Verb) — Twist into a strained configuration. ex. "screw up one's face"